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Creative Biolabs Provides Custom γδ T Cells Products and Servic
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Since the discovery of Gamma delta T cells (γδ T cells), this rare and unique component of the immune system has been recognized for its potential in cancer immunology and immunotherapy. Creative Biolabs is a biotechnology company that has developed an advanced platform to help clients advance their T cell immunotherapy research by providing diverse portfolios of high-quality γδ T cell products and a series of tailored γδ T cell-based drug development and discovery services.
Immunotherapies based on T cells are becoming a huge trend in the treatment of cancer, especially CAR-T cells. These genetically modified T cells have shown remarkable remission rates in patients that did not respond to standard treatments. Among the solutions emerging, a rare type of T cell called Gamma delta T cells (γδ T cells) has attracted a great deal of attention because of their important role in fighting cancer. Besides, a published study revealed that the amount of γδ T cells that infiltrate a tumor was the best predictor of a favorable outcome for the patient.
Given the robust ability and benefits of γδ T cell, Creative Biolabs has focused on exploring γδ T cell technology to speeding up the discovery and development of novel cancer immunotherapies. The services provided by Creative Biolabs include γδ T cell isolation, activation and expansion, characterization, production, cytotoxicity test, and migration assay, aiming to help explore more possible targeted drugs and help scientists develop solutions for cancer.
Immunotherapy with γδ T cells requires their activation and expansion as they comprise only a small percentage of circulating T cells. Appropriate optimization of human T cell activation and expansion protocols can improve the efficiency of genetic modification and overall cell yield. Some of the most commonly studied γδ T cells include Vγ9Vδ2 T cells and non-Vγ9Vδ2 T cells, as they can be activated and expanded in vitro and in vivo, thus make it possible to developing γδ T cell-based immunotherapy.
γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. The phenotypical and functional characterization of γδ T cells can help researchers understand intrinsic factors involved in cellular proliferation, function, and overall processes, and further advance the development of immunotherapy.
Cytotoxicity is the main biological effect of γδT cells and the main way for them to exert anti-tumor effects. “Due to the important function of γδ T cell in several diseases, it is necessary to develop suitable pre-clinical assays for γδ T cell activity and cytotoxicity,” said a scientist at Creative Biolabs.
About Creative Biolabs
Equipped with deep knowledge and experience in γδ T cell design and production, Creative Biolabs can offer high-quality custom γδ T cell solutions for valued clients. Driven by science and a passion for quality, Creative Biolabs is committed to providing comprehensive, low-cost T cells support to meet the needs of customers.