Before booking a seat, many passengers always search about the top cities to travel to in the united states with American airlines. Therefore they ask what cities does American airlines fly in the united states from the preferred destination. You can fly to Los angles, Oakland, Ontario, San Diego, San Francisco, Phoenix, Denver, Dallas, Washington dc, Miami, Honolulu, Chicago, New Orleans, Boston, Detroit, Las Vegas, Manchester, Pittsburgh Seattle, Sant Antonio, Austin, Columbus, etc. in the united states with American airlines.